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If you try to use Skype on your machine having installed a debugger like
SoftIce, Skype wont work, as it is "not compatible with systemdebuggers like
softice". To use it anyway, you can do the following:

before you start skype, set the following breakpoint with softice:

bpx messageboxa

let the computer run ('x'), start skype, press F12 when softice appears,
click the ok button, softice appears again. now, set the EIP to the address
after the ExitProcess instruction with

r eip = ????

for skype 1.0.0.100 it is "r eip = bda605", let it run with "x", now skype
starts without any problem


Manuel